PREPARATION, CHARACTERIZATION, PHARMACOKINETIC, AND THERAPEUTIC POTENTIAL OF NOVEL 6-MERCAPTOPURINE-LOADED ORAL NANOMEDICINES FOR ACUTE LYMPHOBLASTIC LEUKEMIA

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia

Yaru Zou,1,2,* Dong Mei,1,* Jinjie Yuan,1,2 Jiaqi Han,1 Jiamin Xu,1 Ning Sun,1 Huan He,1 Changqing Yang,2 Libo Zhao1 1Clinical Research Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, People’s Republic of China; 2School of Basic Medicine and Clinical Pharmacy

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Luminal-contact-inhibition of epithelial basal stem cell multipotency in prostate organogenesis and homeostasis

Prostate epithelial basal cells are highly plastic in their luminal differentiation capability.Basal stem cells actively produce luminal cells during organogenesis, but become restricted in the adult prostate unless receiving oncogenic or inflammatory stimuli.Given that the number of luminal cells increases relative to basal cells what is wool dobb

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P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.We aimed to investigate the effect of the selective P2X3 antagonist A-317491 on visceral sensitivity under physiological conditions, during acute colitis and in the post-inflammatory phase of c

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N58A Exerts Analgesic Effect on Trigeminal Neuralgia by Regulating the MAPK Pathway and Tetrodotoxin-Resistant Sodium Channel

The primary studies have shown that scorpion analgesic peptide N58A has a significant effect on voltage-gated sodium channels (VGSCs) and plays an important role in neuropathic pain.The purpose of solace nicotine salts this study was to investigate the analgesic effect of N58A on trigeminal neuralgia (TN) and its possible mechanism.The results show

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